B Sustained Release is a high-strength vitamin B complex formulated to release nutrients into the body over an 8-hour period.

B Sustained Release contains B vitamins that help to convert food into energy, and assist the metabolism of protein, carbohydrates and fats.

B Sustained Release assists the synthesis of neurotransmitters and supports nervous system function.

Vitamin B12 and folic acid assist healthy red blood cell production and support blood and cardiovascular system health. Vitamin B6 helps maintain haemoglobin formation.

B Sustained Release contains 400 micrograms of folic acid which, if taken daily for one month before conception and during the first trimester of pregnancy, helps prevent neural tube defects such as spina bifida and anencephaly.

B Sustained Release contains vitamin C, which is an antioxidant that reduces free radicals formed in the body and supports skin health.

• Thiamine hydrochloride (vitamin B1) 100mg
• Riboflavin (vitamin B2) 80mg
• Nicotinamide 100mg
• Calcium pantothenate 120mg (equiv. Pantothenic acid (vitamin B5) 109.9mg)
• Pyridoxine hydrochloride 75mg (equiv. Pyridoxine (vitamin B6) 61.7mg)
• Folic acid 400 micrograms
• Cyanocobalamin (vitamin B12) 100 micrograms
• Choline bitartrate 50mg
• Inositol 50mg
• Biotin 50 micrograms
• Ascorbic acid (vitamin C) 200mg

Adults and children over 12 years: Take 1 tablet daily, with food, or as directed by your health professional.

Does not contain egg, milk, peanut, tree nuts, animal products, gluten, lactose or artificial colours, flavours or preservatives.

WARNINGS:

Contains vitamin B6. Stop taking this medication if you experience tingling, burning or numbness and see your healthcare practitioner as soon as possible. Vitamin supplements should not replace a balanced diet. Advise your doctor of any medicine you take during pregnancy,particularly in your first trimester.

DRUG INTERACTIONS:

Contraindicated with pyrimethamine (antimalarial) - folate may reduce drug effectiveness.

Caution with tetracycline antibiotics - concurrent administration with B2 and B12 may decrease the effectiveness of the medication. Separate dose by 2 hours.

Caution with chloramphenicol (broad spectrum antibiotic) - folic acid and B12 may impact drug metabolism. Separate dose by 2 hours.

Caution with anticholingeric drugs - these drugs reduce the absorption of vitamin B2. Separate dose.

Caution with carbamazepine and primidone - vitamin B3 and folate may impact drug metabolism, resulting in increased drug levels in the body. Monitor use.

Caution with amiodarone - vitamin B6 may increase the risk of drug induced photosensitivity. Separate doses by at least 2 hours.

Caution with levodopa - vitamin B6 may reduce drug effects. However, this effect is prevented by the administration of a dopadecarboxylase inhibitor (e.g. benserazide, carbidopa) with levodopa, as is common clinical practice.

Caution with phenobarbital/phenobarbitone and phenytoin (anticonvulsants) - vitamin B6 and folate may reduce serum concentrations of these drugs.

CAUTIONS:

B vitamins are stimulatory in nature. To avoid any sleep interference, avoid taking before bed.

Taking at night may result in more vivid dreams (vitamin B6).

Caution if there is a history of renal calculi (kidney stones) - vitamin C (ascorbic acid) may increase the risk of recurrence of calcium oxalate calculi.

SIDE EFFECTS:

Supplemental B vitamins may cause nausea or mild gastrointestinal upset if taken on an empty stomach. Best taken with food to reduce the risk.

Riboflavin can impart a bright yellow colour to urine.