Activated Folate 500 contains Quatrefolic a glucosamine salt providing 500mcg 5-MTHF.

Folic acid is a synthetic form of folate that is metabolised in the body to produce 5-MTHF by the enzyme methylenetetrahydrofolate reductase (MTHFR).

Quatrefolic demonstrates a high solubility in water which facilitates absorption by mucosal cells for further circulation in the blood.

5-MTHF is a good form for folate supplementation for people with lower activity of the MTHFR enzyme. It ¢ € ™s also a good alternative to folic acid supplementation as it does not mask vitamin B12 deficiency symptoms.

Activated Folate 500 supports brain health, cognitive function and memory.

Activated Folate 500 supports cardiovascular health by helping to reduce homocysteine levels in the body. It also assists red blood cell production and supports blood health.

Activated Folate 500 supports healthy foetal development.

Activated Folate 500 supports emotional wellbeing and helps prevent dietary folate deficiency.

• Levomefolate glucosamine (Quatrefolic) 1.052mg (equiv. Levomefolic acid (5-MTHF) 500 mcg)

Adults and children over 12 years: Take 1 capsule daily, with food, or as directed by your health professional.

Does not contain egg, milk, peanut, soy, tree nuts, animal products, gluten, lactose or artificial colours, flavours or preservatives.

DRUG INTERACTIONS:

Caution with methotrexate (folic acid antagonist) - co-administration with folate may reduce the effects. Patients should take folate only under the supervision of a health professional.

Caution with phenobarbital and phenytoin (anticonvulsants) - high doses of folate can decrease their efficacy. Monitor.

Caution with antiepileptic and anticonvulsant medications - folate supplements may reduce serum levels of these medications. Patients should take folate only under the supervision of a health professional.

Cholestyramine and colestipol (hypolipidaemic agents) - may decrease the absorption of folate. Separate drugs by at least 4-6 hours.

Several medications may deplete folate status, including antacids (PPIs), trimethoprim (antibiotic), pyrimethamine (antimalarial), triamterene (blood pressure), sulfasalazine (for ulcerative colitis) and oral contraceptives.

CAUTIONS:

None noted at the recommended dose.

SIDE EFFECTS:

None noted at the recommended dose.

COMPANION PRODUCTS:

Activated Sublingual B12

Hawthorn 4500

Pregnancy Plus 1-2-3

Ubiquinol 150mg